Hand prints of some of Australia's biggest movers and shakers will be projected onto Sydney Opera House to kick start a campaign to end indigenous inequality.
Interactive artwork will build up over two hours covering the Opera House sails from 8pm (AEDT) on Friday.
Prime Minister Kevin Rudd, mining magnate Andrew Forrest, media baron James Packer, and actors Russell Crowe and Cate Blanchett will be among the 500 participants at the GenerationOne launch.
The campaign aims to boost aboriginal employment, literacy rates, year 12 completion rates, and help curb alcohol abuse and welfare dependency in indigenous communities.
As part of the launch, artworks will also be projected onto five iconic buildings in other cities - Flinders St Station in Melbourne, the Adelaide Festival Centre, Brisbane City Hall, Canberra Australian National Gallery and the Perth Bell Tower.
Cape York Kokoberra woman Tania Major, the 2007 Young Australian of the Year, is one of faces of the campaign.
"As I get around this country, I find Australians really are unified around a desire to ensure that this is the last generation to suffer indigenous disparity," she said prior to the launch.
Joint spokesman Jack Manning Bancroft said cooperation was needed nationwide.
"GenerationOne is different from previous attempts to fix this problem because it isn't just calling on governments to act. It's calling on business, government and all Australians," he said.
GenerationOne will have a national roadshow from March 23 to May 20 to encourage people to get involved.